In the Cancer Epigenetics and Plasticity Lab we employ outside-the-box thinking to discover mechanisms that regulate cellular plasticity, RNA epigenetics and chromatin organization of cancer cells.

• Role of m6A RNA in the regulation of cancer stemness - Development of first in class epitranscriptome targeting therapeutics

• Role of Histone Deacetylase 7 (HDAC-7) in the regulation of chromatin dynamics and DNA replication of cancer cells

• Role of ERVs in fusion transcripts-Targeting endogenous RdRP activity

• Transcriptional kinetics defining cancer stem cell plasticity - Epigenetic landscape of brain tumors

• Chromatin and transcriptional dynamics of glioma stem cells in hypoxia

• Novel methods to attract and trap migrating cancer cells.

• Role of Egr2-AS-RNA in nerve injury response and genome organization of regenerating glia.